Phanfare:

"maintains your ad-free, branding-free, photo albums on the web using its groundbreaking auto-synchronizing Phanfare Photo software. Instead of having to manipulate a slow and clunky web interface, you interact with our zippy local application on your PC. Everything happens quickly and effortlessly, locally, on your computer. In the background, while you work, we keep your website up to date. Your friends and family access your pictures via the web, while you manage the albums through the reponsive Phanfare Photo application. It's the best of both worlds."

Seems an interesting proposal for $9 a month. Like Flickr, it supports customized URLs but goes one step beyond with the ability to use your own domain name. Phanfare is a .Net app, I heard about it on BeyondVC.